解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The tumour necrosis factor-α (TNF-α) promoter -308 A/G polymorphism plays an important role in the aetiology of systemic lupus erythematosus (SLE). Several studies have estimated the association between TNF-α -308 A/G and SLE risk. However, results were inconsistent. A case-control study was carried out to explore the...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,meta分析
doi:10.1111/sji.12516
更新日期:2017-03-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a common respiratory condition involving the airways and characterized by airflow limitation. Gaseous and noxious particles play an important role in this process. Antioxidants are the substances that may protect cells from the damage caused by unstable molecules known a...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12498
更新日期:2017-02-01 00:00:00
abstract::Approximately 70% of kidney transplant recipients are non-responders to conventional hepatitis B virus (HBV) vaccines. We examined whether Fendrix™, an HBV vaccine containing 3-O-desacyl-4'-monophosphoryl lipid A (MPL) as adjuvant, could induce HBV immunity in these patients and compared their vaccination efficacy wit...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12497
更新日期:2017-01-01 00:00:00
abstract::Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several antinuclear autoantibodies useful to diagnosis and prognosis. The aim of the present multicentric study was to determine the clinical relevance of antifibrillarin autoantibodies (AFA) in patients with SSc. The clinical features of 3...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,多中心研究
doi:10.1111/sji.12510
更新日期:2017-01-01 00:00:00
abstract::This study investigated the expression of the neonatal Fc receptor (FcRn) in maternal blood, cord blood and placental cells and determined IgG levels in maternal blood and cord blood from diabetic mothers. Peripheral blood, cord blood and placenta samples were collected from 26 mothers with normoglycaemia (non-diabeti...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12466
更新日期:2016-10-01 00:00:00
abstract::Eosinophil granulocytes are intriguing members of the innate immunity system that have been considered important defenders during parasitic diseases as well as culprits during allergy-associated inflammatory diseases. Novel studies have, however, found new homoeostasis-maintaining roles for the cell. Recent clinical t...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,评审
doi:10.1111/sji.12448
更新日期:2016-08-01 00:00:00
abstract::Calf spleen extractive injection (CSEI), extracted from the spleen of healthy cows (within 24 h of birth), is a small peptides enriched extraction while the ratio between peptide and ribose is 76 ± 15.2 mg/μg. CSEI is usually used as an ancillary agent to assist cancer patients with immune dysfunction. The present stu...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12442
更新日期:2016-07-01 00:00:00
abstract::Physiological ageing is accompanied by decline in immune system function and immune alteration during ageing increases susceptibility to infections. We retrospectively analysed the data for complete blood count (CBC) and lymphocyte subsets from infant to elderly age groups to determine changes during ageing. Data from...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12413
更新日期:2016-04-01 00:00:00
abstract::In this review, we summarize and discuss some key findings from the study of naturally occurring autoantibodies. The B-cell compartment of the immune system appears to recognize almost all endogenous and environmental antigens. This ability is accomplished principally through autopolyreactive humoral and cellular immu...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,评审
doi:10.1111/sji.12414
更新日期:2016-04-01 00:00:00
abstract::We have previously shown that immunization of outbred rodents with cysteine peptidases-based vaccine elicited type 2-biased immune responses associated with consistent and reproducible protection against challenge Schistosoma mansoni. We herein start to elucidate the molecular basis of C57BL/6 mouse resistance to S. m...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12399
更新日期:2016-02-01 00:00:00
abstract::There is an increasing need for novel biomarkers that enable better diagnostic and prognostic stratification of patients with suspected infection. A proprotein convertase enzyme FURIN is upregulated upon immune cell activation, and it promotes infectivity by cleaving and activating pathogens. In this study, we determi...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12386
更新日期:2015-12-01 00:00:00
abstract::Granulomatous lymphomatosis is an Epstein-Barr virus (EBV)-driven B cell proliferation associated with an exuberant CD4(+) T cell reaction with usually histopathological pictures of angiocentrism. So far, the characteristics of CD4(+) T cells in granulomatous lymphomatosis and the mechanism leading to their expansion ...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12370
更新日期:2015-12-01 00:00:00
abstract::Haem oxygenase-1 (HO-1) plays an important role in inflammatory disease development and progression. Whether it has an anti-inflammatory role in lipopolysaccharide (LPS)-induced liver injury remains unclear. To investigate the functional role of HO-1 in protecting liver tissue against inflammatory response stimulated ...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12352
更新日期:2015-11-01 00:00:00
abstract::Foot-and-mouth disease (FMD) caused by FMD virus (FMDV) is a major health and economic problem in the farming industry. Vaccination of livestock against this highly infectious viral disease is crucial, and inactivated FMD vaccine has been effective at controlling infection. However, accumulated data show that the inac...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12349
更新日期:2015-11-01 00:00:00
abstract::Adaptive immunity is a complex system that appeared twice in vertebrates (in gnathostomes and in jawless fish) although it is not required for invertebrate defence. The adaptive immune system is tightly associated with self-non-self discrimination, and it is now clear that this interplay is not limited to the preventi...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,评审
doi:10.1111/sji.12348
更新日期:2015-11-01 00:00:00
abstract::Lymphatic filariasis, a mosquito-borne parasitic disease, affects more than 120 million people worldwide. Vaccination for filariasis by targeting different stages of the parasite will be a boon to the existing MDA efforts of WHO which required repeated administration of the drug to reduce the infection level and susta...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12340
更新日期:2015-10-01 00:00:00
abstract::Chronic inflammatory diseases are now treated with a range of different biopharmaceuticals, often requiring lifelong parenteral administrations. This exposure to drugs is unnatural and can trigger the immune system and result in the formation of antidrug antibodies. Drug-specific antibodies will, if of sufficiently hi...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,评审
doi:10.1111/sji.12327
更新日期:2015-09-01 00:00:00
abstract::Persistent humoral immunity depends on the follicular B cell response and on the generation of somatically mutated high-affinity plasma cells and memory B cells. Upon activation by an antigen, cognately activated follicular B cells and follicular T helper (TFH ) cells initiate germinal centre (GC) reaction during whic...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,评审
doi:10.1111/sji.12336
更新日期:2015-09-01 00:00:00
abstract::Ebola viruses (EBOVs) have been identified as an emerging threat in recent year as it causes severe haemorrhagic fever in human. Epitope-based vaccine design for EBOVs remains a top priority because a mere progress has been made in this regard. Another reason is the lack of antiviral drug and licensed vaccine although...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12302
更新日期:2015-07-01 00:00:00
abstract::Autoimmune regulator's (AIRE) best characterized role is in the generation immunological tolerance, but it is also involved in many other processes such as spermatogenesis. Loss-of-function mutations in AIRE cause a disease called autoimmune polyendocrinopathy, candidiasis and ectodermal dystrophy (APECED; also called...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12280
更新日期:2015-05-01 00:00:00
abstract::KIR2DL2 and KIR2DL3 are important inhibitory receptors that recognize a subset of HLA-C allelic products carrying Ser77 and Asn80. In this study, we have determined KIR2DL2 and KIR2DL3 diversity in the Chinese Han population by a PCR sequence-based typing. Based on sequencing, the coding regions of 166 Chinese Han ind...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12277
更新日期:2015-04-01 00:00:00
abstract::The intestinal microbiota is important for tolerance induction through mucosal immunological responses. The composition of the gut microbiota of an infant is affected by environmental factors such as diet, disease and antibiotic treatment. However, already in utero, these environmental factors can affect the immunolog...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12205
更新日期:2014-10-01 00:00:00
abstract::The immunological paradox of pregnancy, when maternal immune system recognizes but does not reject the semiallogenic foetus, is not yet fully understood. The aim of this work was to detail the mechanisms of the interaction of decidual CD56+ NK, infiltrating the maternal part of placenta, and trophoblast cells of foeta...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12196
更新日期:2014-09-01 00:00:00
abstract::Experimental autoimmune neuritis (EAN), an animal model of human Guillain-Barré syndrome, has long been considered as a T helper (Th) 1 cell-mediated autoimmune disorder. However, deficiency of IFN-γ, a signature Th1 cytokine, aggravated EAN, with features of elevated production of IL-17A, despite an alleviated system...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12201
更新日期:2014-09-01 00:00:00
abstract::Vitamin A is a potential mediator of T helper cells in atherosclerosis. The purpose of this study was to evaluate the effect of vitamin A supplementation on expression of Th17 cells-related IL-17 and RORc genes in atherosclerotic patients. Thirty one atherosclerotic patients and 15 healthy controls were studied for 4 ...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,随机对照试验
doi:10.1111/sji.12190
更新日期:2014-08-01 00:00:00
abstract::High-grade glioma is a malignant tumour; the pathogenesis is to be further investigated. Interleukin (IL)-17 is an inflammatory cytokine. Chronic inflammation is a pathological feature of cancer. This study aimed to characterize the glioma-derived IL-17(+) regulatory T cells (Treg). In this study, single cells were is...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12185
更新日期:2014-08-01 00:00:00
abstract::CD172α and CD47 are members of glycoprotein expressed on macrophages and various immune cells, promote immune recognition and T cell stimulation that priming phagocytosis of pathogens and apoptotic bodies and malignant cell. Tumour-releasing immunosuppressive factor promotes tumour growth and transforms the tumour res...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12180
更新日期:2014-07-01 00:00:00
abstract::Schizophrenia is one of the most debilitating diseases among psychiatric disorders. Recent studies suggest the existence of effective immunological changes in the pathophysiology of this disease. The purpose of the current study was to determine the changes in serum levels of Brain Derived Neurotrophic Factor (BDNF) a...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12158
更新日期:2014-07-01 00:00:00
abstract::Infection with murine gammaherpesvirus 68 has become an accepted model for studying the virus/host interactions with regard to gammaherpesvirus infections. Previous studies using gene-deficient mice have revealed that neither IFNγ nor perforin is essential in controlling the outcome of infection or the virus load duri...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12176
更新日期:2014-06-01 00:00:00
abstract::Blood levels of regulators of the complement system in preterm babies were reported in few studies only. The aim of this study was to set up a complement profile in premature and term babies focusing on the development of blood levels of MBL, key regulatory proteins and on classical pathway activity, which may allow a...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12154
更新日期:2014-04-01 00:00:00
abstract::Anti-inflammation strategy is one of the proposed therapeutic approaches to hepatic fibrosis. T helper (Th) 17 cells, which play a detrimental role in experimental murine models of inflammatory diseases, have been demonstrated to participate in the pathogenesis of liver damage. The inhibitory effect of halofuginone (H...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12144
更新日期:2014-03-01 00:00:00
abstract::Vitamin D, an immunomodulator of macrophage function, can activate human antimycobacterial activity. Vitamin D deficiency (VDD) is associated with an impaired mycobacterial immunity and susceptibility to tuberculosis. It has been found that vitamin D and its receptor may be essential for immune function. In this study...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12127
更新日期:2014-02-01 00:00:00
abstract::Tumour necrosis factor-α-induced protein-8 like-2 (TIPE2) is a newly identified immune negative regulator. The abnormal expression of TIPE2 has been found in several human inflammatory diseases. However, the expression level and clinical significance of TIPE2 in childhood asthma remain unclear. In this study, we detec...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12110
更新日期:2013-12-01 00:00:00
abstract::Cutaneous leishmaniasis (CL) is a self-healing skin disease which rarely for unknown reason(s) the lesion develops to a non-healing form. It seems that the initial contact of Leishmania parasites with the host innate immune system is an important step in the outcome of the disease. Recent studies suggested that toll-l...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12105
更新日期:2013-11-01 00:00:00
abstract::Hyper-IgE syndrome (HIES) is a rare primary immunodeficiency disease characterized by eczema, recurrent staphylococcal aureus skin abscesses, pneumonia with pneumatocele formation, remarkably high serum IgE levels, eosinophilia and involvement of skeleton and connective tissues. Heterozygous signal transducer and acti...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12063
更新日期:2013-09-01 00:00:00
abstract::Many patients with inflammatory bowel disease (IBD) are undergoing therapy with infliximab, an antibody specific for TNF. However, the exact mechanisms of action of infliximab are not completely understood. The aim of this study was to determine the in vitro effects of infliximab on blood T cells derived from anti-TNF...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12081
更新日期:2013-09-01 00:00:00
abstract::Atrial fibrillation is highly prevalent, and affected patients are at an increased risk of a number of complications, including heart failure and thrombo-embolism. Over the past years, there has been increasing interest in the role of inflammatory processes in atrial fibrillation, from the first occurrence of the arrh...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,评审
doi:10.1111/sji.12061
更新日期:2013-08-01 00:00:00
abstract::BTK and ITK are cytoplasmic tyrosine kinases of crucial importance for B and T cell development, with loss-of-function mutations causing X-linked agammaglobulinemia and susceptibility to severe, frequently lethal, Epstein-Barr virus infection, respectively. Over the last few years, considerable efforts have been made ...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,评审
doi:10.1111/sji.12069
更新日期:2013-08-01 00:00:00
abstract::C-reactive protein (CRP) binds to Fcγ-receptors, FcγRIIa (CD32) with high affinity and to FcγRIa (CD64) with low affinity. The binding to CD32 has been shown to be allele specific, that is, it binds to R/R131 but not to H/H131. Little is known about the cooperation of CRP and neutrophilic granulocytes (PMNs) in inflam...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12049
更新日期:2013-06-01 00:00:00
abstract::The effector functions of IgG depend on the presence of carbohydrates attached to asparagine 297 in the Fc-portion. In this report, glycosylation profiles of recombinant wild-type and mutant IgG1 and IgG3 antibodies produced from three cell lines were analysed using LC-ESI-Orbitrap. Clear differences were detected bet...
journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/sji.12046
更新日期:2013-05-01 00:00:00